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5' flanking region : ウィキペディア英語版 | 5' flanking region The 5' flanking region is a region of DNA that is adjacent to the 5' end of the gene. The 5' flanking region contains the promoter, and may contain enhancers or other protein binding sites. It is the region of DNA that is not transcribed into RNA. ==Polymorphisms== Flanking SNPs are Single nucleotide polymorphisms (SNP) that appear in the flanking region. Polymorphisms in this region can lead to changes in the regulation of transcription. They have also been associated with a number of diseases. A 12 base pair insertion in the 5' flanking region of the Cystatin B gene has been linked to some individuals with Unverricht-Lundborg disease. Polymorphisms in the 5' flanking region of the DRD4 gene have been linked to ADHD, schizophrenia and methamphetamine abuse. Insertions and deletions in the 5' flanking region of the insulin gene have been associated with type 2 diabetes. Polymorphisms in the 5' flanking region of the gene coding for oxytocin have been linked to mutations in promoter function, ultimately leading to potential disorders related to altered oxytocin levels and functionality.
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「5' flanking region」の詳細全文を読む
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